Emerging infectious diseases represent major threats to global security, economic development, and human and animal health. Over 70% of emerging infectious diseases today are zoonotic, and developing regions, particularly sub-Saharan Africa, are recognized as hotspots of newly emerging zoonotic microbes and multi-drug resistant bacteria. Dr. Gebreyes (Principal Investigator) and the Global One Health team were recently awarded a 5-year $4.65M cooperative agreement with the Centers for Disease Control and Prevention “Global Health Security Partner Engagement: Expanding Efforts and Strategies to Protect and Improve Public Health Globally”. The Global One Health team is an interdisciplinary group of faculty and staff from the Colleges of Veterinary Medicine, Medicine, Public Health, Nursing, Communications, Ohio Agricultural Research and Development Center, and the Office of International Affairs Global One Health Initiatives. The cooperative agreement will support efforts to prevent zoonotic diseases (brucellosis and rabies) and prevent antimicrobial resistance in Ethiopia. Dr. Gebreyes and the Global One Health team will work closely with the Ethiopian Public Health Institute and technical teams from the CDC and American Society for Microbiology in Ethiopia to conduct surveillance, build infrastructure and communications, and assist the Ethiopian government with addressing its public health priorities in zoonotic diseases and antimicrobial resistance.