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Publications (last three to five years)

Recent Peer Reviewed Publications (selected from a total of 75 peer-reviewed publications and 7 book chapters; a complete list of published work can be found at perle.1/bibliography/44624467/public/?sort=date&direction=ascending):


  1. Caserta E. Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, Srivastava A, Yu L, Wallace J, Mo X, Park M, Fernandez SA, Pilarski R, La Perle KM, Rosol TJ, Coppola V, Castrillon DH, Timmers C, Cohn DE, O’Malley DM, Backes F, Suarez AA, Goodfellow P, Chamberlin HM, Macrae E, Shapiro CL, Ostrowski MC, Leone G. Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes & Development 15: 1707-1720, 2015, PMID 26302789, PMC4561480.
  2. Gressel KL, Duncan JF, Oberyszyn TM, La Perle KM, Everts HB. Endogenous retinoic acid required to maintain the epidermis following ultraviolet light exposure I SKH-1 hairless mice. Photochemistry and Photobiology 91: 901-908, 2015, PMID 25715879, PMC4509636.
  3. Berman-Booty LD, Thomas-Ahner JM, Bolon B, Oglesbee MJ, Clinton SK, Kulp SK, Chen C-S, La Perle KMD. Extra-prostatic transgene-associated neoplastic lesions in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice. Toxicologic Pathology 43: 186-197, 2015, PMID 24742627, PMC4201646.
  4. Ding H, Casto B, Deng Y, Grill K, Duan W, Zhang N, Cole S, La Perle KMD, Pan X, Kinghorn AD, D’Ambrosio SM. Avocado extract inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis in hamster cheek pouches. Medicinal Chemistry S1-S8, 2014.
  5. La Perle KMD, Green MG, Niewiesk S. Trophoblast Deportation to the Lungs of Cotton Rats (Sigmodon hispidus). Comparative Medicine 64: 448-455, 2014, PMID 25527025, PMC4275080.
  6. Yang J, Bill MA, Young GS, La Perle K, Landesman Y, Shacham S, Kauffman M, Senapedis W, Kashyap T, Saint-Martin J-R, Kendra K, Lesinski GB. Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells. PLOS one 9: e102983, 1-12, 2014, PMID 25057921, PMC4109950.
  7. Murrey DA, Naughton BJ, Duncan FJ, Meadows AS, Ware TA, Campbell KJ, Bremer WG, Walker CM, Goodchild L, Bolon B, La Perle K, Flanigan KM, McBride KL, McCarty DM, Fu H. Feasibility and safety of systemic rAAV9-hNAGLU delivery for treating Mucopolysaccharidosis IIIB: Toxicology, biodistribution and immunological assessments in primates. Human Gene Therapy Clinical Development 25: 72-84, 2014, PMID 24720466/24617499, PMC4124586.
  8. Pringle DR, Vasko VV, Yu L, Manchanda PK, Lee AA, Zhang X, Kirschner JM, Parlow AF, Saji M, Jarjoura D, Ringel MD, La Perle KM, Kirschner LS. Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid specific deletion of Prkar1a and Pten in mice. Journal of Clinical Endocrinology & Metabolism 99: E804-E812, 2014, PMID 24512487, PMC4010710.
  9. Marshall JM, Flechtner AD, La Perle KM, Gunn JS. Visualization of extracellular matrix components within sectioned Salmonella biofilms on the surface of human gallstones. PLoS ONE 9: e89243, 1-9, 2014, PMID 24551241, PMC3925243.
  10. De Lorenzo MS, Chen W, Baljinnyam E, Carlini MJ, La Perle K, Bishop SP, Wagner TE, Rabson AB, Vatner DE, Puricelli LI, Vatner SF. Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption. Aging Cell 13: 102-110, 2014, PMID 23957304, PMC3980454.
  11. Gonzalez-Escobedo G, La Perle KM, Gunn JS. Histopathological analysis of Salmonella chronic carriage in the hepatopancreatobiliary system. PLoS ONE 8: e84058, 1-14, 2013, PMID 24349565, PMC3861519.
  12. Manchanda PK, Jones GN, Lee AA, Pringle DR, Zhang M, Yu L, La Perle KMD, Kirschner LS. Rac1 is required for Prkar1a-mediated Nf2 suppression in Schwann cell tumors. Oncogene 32: 3491-3499, 2013, PMID 23045281, PMC3542412. 
  13. La Perle KMD, Kim DC, Hall NC, Bobbey A, Shen DH, Nagy R, Wakely Jr. PE, Lehman A, Jarjoura D, Jhiang SM. Modulation of sodium/iodide symporter expression in the salivary gland. Thyroid 23: 1029-1036, 2013, PMID 23441638, PMC3752512.
  14. Rosas LE, Grieves JL, Zaraspe K, La Perle KM, Fu H, McCarty DM. Patterns of scAAV vector insertion associated with oncogenic events in a mouse model for genotoxicity. Molecular Therapy 20: 2098-2110, 2012, PMID 22990674, PMC3498805.
  15. Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal K. Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. Journal of Clinical Investigation 122: 2871-2883, 2012, PMID 22820288, PMC3408748.
  16. Pringle DR, Yin Z, Lee AA, Manchanda PK, Yu L, Parlow AF, Jarjoura D, La Perle KMD, Kirschner LS. Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer. Endocrine-related Cancer 19: 435-446, 2012, PMID 22514108, PMC3667702.
  17. Berman-Booty LD, Garzel LM, Bergdall V, La Perle KMD. A prostate fibromyxoid sarcoma with smooth muscle differentiation in a F344XBNF1 rat. Veterinary Pathology 49: 642-647, 2012, PMID 22262352.
  18. Jacob A, Oblinger J, Bush ML, Brendel V, Santarelli G, Chaudhury AR, Kulp S, La Perle KMD, Chen C-S, Chang, L-S, Welling DB. Preclinical validation of AR42, a novel histone deacetylase inhibitor, as treatment for vestibular schwannomas. Laryngoscope 122: 174-189, 2012, PMID 22109824, PMC3384504.
  19. Bolon B, Couto S, Fiette L, La Perle K. Internet and print resources to facilitate pathology analysis when Phenotyping genetically engineered rodents. Veterinary Pathology 49:224-235, 2012, PMID 21825311.
  20. Christoforidis J, Ricketts R, Pratt C, Pierce J, Bean S, Wells M, Zhang X, La Perle K. The effect of intravitreal anti-VEGF agents on peripheral wound healing in a rabbit model. Clinical Ophthalmology 6: 61-69, 2012, PMID 22275809, PMC3261691.
  21. Mundy-Bosse BL, Lesinski GB, Jaime-Ramirez AC, Benninger K, Khan M, Kuppusamy P, Guenterberg K, Kondadasula SV, Ray Dhaudhury A, La Perle KM, Kreiner M, Young GS, Guttridge DC, Carson WE. Myeloid-derived suppressor cell inhibition of the IFN response in tumor-bearing mice. Cancer Research 71: 5101-5110, 2011, PMID 21680779, PMC3148319.
  22. Saji M, Narahara K, McCarty SK, Vasko VV, La Perle KM, Porter K, Jarjoura D, Lu C, Cheng SY, Ringel MD. Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. Oncogene 30: 4307-4315, 2011, PMID 21532616, PMC3151477.
  23. He H, Grignol V, Karpa V, Yen C, LaPerle K, Zhang X, Jones NB, Liang MI, Lesinski GB, Ho WS, Carson WE, Lee LJ. Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatment. Journal of Controlled Release 151: 239-245, 2011, PMID 21362447.
  24. Jaime-Ramirez AC, Mundy-Bosse BL, Kondadasula S, Jones NB, Roda JM, Mani A, Parihar R, Karpa V, Papenfuss TL, LaPerle KM, Biller E, Lehman A, Chaudhury AR, Jarjoura D, Burry RW, Carson WE. IL-12 enhances the antitumor actions of trastuzumab via NK cell IFN-Y production. Journal of Immunology 186: 3401-3409, 2011, PMID 21321106, PMC3593307.
  25. Gravaghi C, La Perle KM, Ogrodwski P, Kang JX, Quimby F, Lipkin M, Lamprecht SA. Cox-2 expression, PGE(2) and cytokines production are inhibited by endogenously synthesized n-3 PUFAs in inflamed colon of fat-1 mice. Journal of Nutritional Biochemistry 22: 360-365, 2011, PMID 20655721.

Recent Book Chapters (selected from a total of 6 book chapters)

  1. La Perle KMD and Couto SS. Mouse Models of Hematologic Malignancies. In C. H. Dunphy (Ed.), Molecular Pathology of Hematolymphoid Malignancies, Springer, 2010, New York, pp. 203-208.
  2. La Perle KMD and Capen CC. Endocrine System. In M. D. McGavin and J. F. Zachary (Eds.), Pathologic Basis of Veterinary Disease, 4th Edition, 2007, Mosby Elsevier, St. Louis, pp. 693-741.
  3. La Perle KMD and Jhiang SM. Iodine: Symporter and oxidation, thyroid hormone biosynthesis. In H. L. Henry and A. W. Norman (Eds.), Encyclopedia of Hormones, Volume 2 of 3, 2003, Academic Press, San Diego, pp. 517-522.