Vitamin D metabolites, parathyroid hormone and fibroblast growth factor-23 – Klotho Axis in dogs with various stages of chronic kidney disease


The purpose of this study is to determine how various nutritional and hormonal factors are affected in dogs with chronic kidney disease (CKD). We will evaluate concentrations of vitamin D metabolites and other hormones (e.g., parathyroid hormone) that can affect the development of renal secondary hyperparathyroidism (RHPT) in order to then develop novel medical and dietary therapeutic strategies.

Inclusion Criteria

  • Dog must be diagnosed with CKD and staged by the International Renal Interest Society guidelines
  • Dog must be at least one year of age

  • Dog must not be diagnosed with any other disease known to affect vitamin D or PTH concentrations

First your dog will have a physical examination and blood pressure measurement. Then your dog will have blood and urine collected to evaluate a complete blood count (CBC), serum biochemistry profile, ionized calcium, urinalysis, urine protein: creatinine (UPC) ratio and urine culture. A small amount of blood will be stored for later evaluation of your dog’s vitamin D status and other hormones that are known to play a role in the development of RHPT. Your dog will only need to have blood and urine collected at one time and the total amount of blood collected is considered very safe for dogs. In some animals, venipuncture may result in bruising or hematoma formation at the site of blood collection. In rare cases, cystocentesis may result in hematuria or infrequently bladder rupture.

Client Compensation:

  • The study will cover the costs of a CBC, biochemistry profile, ionized calcium, urinalysis, UPC, urine culture and blood pressure, vitamin D metabolite and hormone concentrations.

Client Cost:

  • Owners are responsible for all other costs.

Client Contact:

Dr. Valerie Parker Phone: (614) 292-3551; Email: Parker [dot] 888 [at] osu [dot] edu