2007 Distinguished Research Career Award
Kuan-Teh Jeang, M.D., Ph. D., Head, Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
Dr. Kuan-Teh Jeang is a prolific leader in the field of molecular virology. His research on the gene regulation of human immunodeficiency virus (HIV-1) and carcinogenic mechanisms of human T-cell leukemia virus type 1 (HTLV-1) has produced 230 peer-reviewed articles, to date. His significant contributions have provided fundamental information into viral and cellular factors that regulate expression of these pathogenic human retroviruses and insights into methods to improve HIV-1-based vectors, design molecular ribozymes targeted against HIV-1, and to identify small antiviral molecules. Some of his notable scientific findings include elucidation of a mechanism for suppression of p53, defining virally-encoded factors that select against HIV-1 CXCR4-tropism, and identification of a mitotic checkpoint protein whose function is abrogated by HTLV-I Tax oncoprotein. His recent pioneering research has demonstrated that deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in a mouse model, identified that the HIV-1 Tat protein binds Dicer, a key regulator of small interfering RNA, and described a role for Akt/protein kinase B and activator protein-1 in cellular proliferation induced by HTLV-1 Tax.
Dr. Jeang received the engraved crystal award sculpture and presented the special lecture "HTLV-1, Adult T-cell Leukemia, and Mechanisms of Cellular Transformation". Dr. Jeang presented a second lecture entitled "HIV-1 and small RNAs: what we are learning", both in April 2007 at the College of Veterinary Medicine on the campus of The Ohio State University.
Dr. Jeang's visit was sponsored jointly by the Center for Retrovirus Research and and the Dept of Veterinary Biosciences, Dept of Molecular Virology, Immunology and Medical Genetics, and the Comprehensive Cancer Center program in Viral Oncogenesis.
Dr. Kuan-Teh Jeang (right) receives Career Award crystal from Dr. Michael Lairmore
Dr. Jeang with Retrovirus Center members (from left, Drs. Patrick Green, Kathleen Boris-Lawrie, Kuan-Teh Jeang, and Michael Lairmore.
Dr. Jeang presents a second lecture at the Retrovirus Center weekly Lab Meeting.