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Yasuko Rikihisa, PhD
University Distinguished Professor
Member, National Academy of Sciences
Department of Veterinary Biosciences

The Ohio State University
1925 Coffey Rd.
Columbus, Ohio 43210
Ph: (614) 292-9677
Fx: (614) 292-6473

Professional Training and Experience

  • PhD, MS, University of Tokyo
  • Postdoctoral Fellow, Harvard Medical School

Research Interests

The Rikihisa Laboratory

  • Understanding the molecular pathogenic mechanisms of ehrlichiosis/anaplasmosis, vector-borne emerging infectious diseases of man (zoonosis) and animals. 
  • Elucidation of Ligand and Receptor, and Invasion Mechanisms of Intracellular Bacteria.
  • Determination of Nutritional Virulence of Intracellular Bacteria-Hijacking Autophagy Pathway by Bacterial Molecules Secreted by Type IV Secretion System.
  • Analysis of Regulation of Intracellular Growth and Development by Bacterial Two-component Regulatory System.
  • Investigation of Ehrlichia strain-variable Disease Pathogenesis In vivo Virulence Linked to Comparative Genome Sequence and Transcriptome Analysis
  • Isolation, and Molecular and Antigenic Characterization of New Ehrlichia, Anaplasma, and Neorickettsia spp., Aegyptianella and Haemotropic Mycoplasma.
  • Test Disease Intervention Strategy by using Animal models of Potomac horse fever, canine ehrlichiosis, human monocytic ehrilichiosis, and human granulocytic anaplasmosis.
  • Development of Vaccines and Diagnostic Procedures: PCR, dot blot, Western blot, IFA, ELISA, culture isolation, cloning protective and diagnostic antigens. 
  • Analysis of Molecular Mechanisms of Vector (tick, trematode) transmission, and determination of Natural Reservoirs.